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The Science of Creatine: What It Does, Who It’s For and Why It Works

By Maureen Farrar

If you’re looking to boost your workouts, build muscle, or maybe even ward off some health issues down the road, you might be curious about creatine. It’s a natural substance found in your body that helps your muscles get the energy they need.

It’s not only considered a safe supplement for most people but, next to protein, it’s also one of the most popular and effective options out there for boosting athletic performance and muscle growth. In fact, it’s so popular that one study found that around 14% of college athletes use it.

But how does creatine actually work? What are the real benefits and risks? We’ve got you covered. We’ll break down the science behind creatine and help you decide if it’s the right fit for your fitness goals.

What is Creatine?

Creatine is a molecule naturally produced in your body from amino acids, The majority of creatine is made in your liver, with some help from your kidneys and pancreas, and it plays a role in energy production, especially under demanding conditions like physical activity. 

While your body makes some creatine on its own, about half of your supply comes from the food you eat, particularly protein-rich options like red meat, seafood, and certain types of milk. But if you want an extra boost, many people turn to creatine supplements.

These supplements are especially popular among athletes involved in sports that require short bursts of intense energy, like weightlifting, football, or sprinting. The most common type is creatine monohydrate, which has been shown to improve muscle performance during high-intensity exercise.

What Are the Benefits of Creatine?

Research shows that supplementing with creatine helps you muscle cells produce more energy, enhances exercise performance, and speeds up muscle growth. More data is showing that creating is beneficial for women, especially as we get older. 

Here’s more on these benefits. 

Promotes Energy Production in Muscles

During exercise, your muscles break down ATP (adenosine triphosphate) to generate the energy needed for movement. The faster your body can resynthesize ATP, the longer and harder you can work at maximum intensity.

Creatine supplements enhance your muscle’s ability to produce ATP by increasing phosphocreatine stores, a key compound in the ATP regeneration process. This translates to a more readily available supply of energy for your muscles during high-intensity exercise, allowing for improved performance and potentially delaying fatigue.

Improves Exercise Performance

Research suggests that creatine is key to significantly enhancing performance during high-intensity exercise. It’s been shown to improve various factors, including strength, power, sprint ability, muscle endurance, muscle growth, and even recovery time.

Interestingly, studies indicate that creatine supplements can benefit individuals across all fitness levels, from beginners to seasoned athletes, setting it apart from other supplements that primarily benefit those with more advanced training backgrounds.

Speeds Up Muscle Growth

Creatine has proven to be highly effective in supporting muscle growth and promoting rapid gains in muscle mass. Studies demonstrate that even short-term creatine supplementation, lasting as little as five to seven days, can lead to a noticeable increase in lean body mass and muscle size in athletes.

Supports Bone Health (Especially in Postmenopausal Women)

Bone health is another area where creatine shines, particularly for women navigating menopause and beyond. The key to staying active and mobile throughout your life is maintaining strong bones. 

Whether you’re doing everyday tasks or hitting the gym, those activities cause your muscles to pull on your bones, and just like muscles, bone cells need energy, too. Creatine helps provide it.

For women in menopause or postmenopause, this is even more important. Declining estrogen levels significantly increase the risk of osteoporosis, a condition that weakens bones and makes them more prone to fractures.

Related: The Scoop on Protein Powders

Are There Risks to Taking Creatine?

Concerns about potential side effects like bloating, dehydration, and muscle cramps sometimes lead people to avoid creatine supplementation. However, despite these worries, extensive research conducted by the International Society of Sports Nutrition positions creatine as one of the safest and most advantageous supplements for athletes.

However, some side effects may include weight gain, and digestive issues.

Weight Gain

Studies indicate that taking creatine supplements can lead to a noticeable increase in body weight shortly after beginning supplementation. This initial weight gain, however, is typically attributed to water retention within the muscles, not an increase in body fat. Over time, any further increases in body weight are likely due to muscle growth, supported by the enhanced performance and recovery benefits associated with creatine use.

Dehydration

Creatine works by pulling water into your muscles, which is why it’s important to stay well-hydrated throughout the day, especially when you’re working out. While there are concerns that creatine can cause dehydration, research suggests that it helps your body retain water when you’re drinking enough fluids. 

Digestive Issues

If you take too much creatine at once, you can experience digestive issues. One study showed that 29% of participants who took a 5-gram dose twice a day experienced diarrhea and mild discomfort. For this reason, the recommended dose is 3-5 grams once a day. 

The Bottom Line

Creatine supplements are generally considered safe for most people and offer potential benefits like increased muscle growth and enhanced energy production during high-intensity exercise. Creatine also supports bone health, especially in older women. If you’re thinking of adding creatine to your supplement regimen, consult with a healthcare provider before starting. 

Related: Supplements vs. Food

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